How a specific protein helps neutrophils fight bacterial infections
Neutrophil-intrinsic role of SLC11A1/NRAMP1 in control of bacterial infection
This study is looking at how a protein called SLC11A1 helps white blood cells called neutrophils fight off bacterial infections like Salmonella, which could help us find better ways to treat these infections in people who are more vulnerable to them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10772361 on NIH RePORTER |
What this research studies
This research investigates the role of the SLC11A1 protein in neutrophils, a type of white blood cell, in controlling bacterial infections, particularly Salmonella. The study aims to uncover how this protein enhances the ability of neutrophils to kill bacteria and how deficiencies in this protein can lead to increased susceptibility to infections. By using various experimental approaches, the researchers will explore the specific functions of SLC11A1 in neutrophils and its impact on disease pathology. This could lead to a better understanding of immune responses and potential new treatments for bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of recurrent bacterial infections or those with autoimmune conditions that may affect neutrophil function.
Not a fit: Patients with infections caused by viruses or fungi may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating bacterial infections, particularly in individuals with weakened immune systems.
How similar studies have performed: Previous research has shown promising results regarding the role of SLC11A1 in macrophages, but this investigation into its function in neutrophils is novel.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Tsolis, Renee M — University of California at Davis
- Study coordinator: Tsolis, Renee M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.