How a specific protein helps neutrophils fight bacterial infections
Neutrophil-intrinsic role of SLC11A1/NRAMP1 in control of bacterial infection
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-10683118
This study is looking at how a specific protein in immune cells helps fight off bacterial infections, especially when someone doesn't get enough vitamin A, and it aims to find new ways to improve our immune response to these infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-10683118 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the SLC11A1/NRAMP1 protein in neutrophils, a type of immune cell, and how it helps control infections caused by bacteria like Salmonella. The study aims to uncover new mechanisms by which neutrophils can effectively combat bacterial pathogens, particularly in the context of vitamin A deficiency. By examining the differences in neutrophils with and without functional SLC11A1, the researchers hope to identify how this protein enhances the immune response against infections. The findings could lead to a better understanding of immune function and potential new treatments for bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune diseases or those at risk for severe bacterial infections.
Not a fit: Patients with non-bacterial infections or those not affected by immune system deficiencies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bacterial infections, particularly for patients with weakened immune systems.
How similar studies have performed: Previous research has shown promising results in understanding immune responses, but the specific role of SLC11A1 in neutrophils is a novel area of investigation.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TSOLIS, RENEE M — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: TSOLIS, RENEE M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder, autoimmunity disease, Bacterial Infections, bacteria infection