How 3D genome structure affects allergic responses
Official title: 3D genome organization of the Ets1-Fli1 locus controls allergic responses
Funded at University of Pennsylvania · NIH-10885120 · Data updated 2026-11-12
This study is looking at how the way our genes are organized in 3D space affects the behavior of important immune cells called CD4+ T cells, which play a key role in allergies, to help us understand how genetic differences might lead to conditions like asthma and skin allergies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 10, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $772,175 |
| NIH project number | 5R01AI168136-02 |
| Project ID | NIH-10885120 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with allergic diseases such as asthma, atopic dermatitis, or other immune-mediated conditions.
✕Less likely to help
Patients without allergic disorders or those with unrelated immune conditions may not benefit from this research.
What this research studies
This research investigates the role of three-dimensional (3D) genome organization in the function of CD4+ T cells, which are crucial in mediating allergic disorders. By examining how changes in the spatial arrangement of genes and regulatory elements influence T cell behavior, the study aims to uncover the molecular mechanisms linking genetic variations to allergic diseases. The approach involves advanced algorithms to analyze the interactions of genomic elements and their impact on immune responses, particularly in conditions like asthma and atopic dermatitis.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic basis of allergic disorders, potentially informing targeted therapies.
How similar studies have gone: While the specific approach of linking 3D genome organization to allergic responses is novel, related research has shown promise in understanding immune-mediated diseases through genomic studies.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Vahedi, Golnaz — University of Pennsylvania
- Study coordinator: Vahedi, Golnaz
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.