High-speed 3D imaging of brain activity
Official title: Mesoscopic microscopy for ultra-high speed and large-scale volumetric brain imaging
Funded at Johns Hopkins University · NIH-11089404 · Data updated 2026-11-12
This study is exploring a new way to see how the brain works by using special imaging techniques on zebrafish, which could help us understand brain activity better and improve our knowledge of brain disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $465,511 |
| NIH project number | 5R01EB034272-03 |
| Project ID | NIH-11089404 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in neurological conditions or those with a specific interest in brain imaging technologies.
✕Less likely to help
Patients with conditions unrelated to brain function or those not eligible for imaging studies may not benefit from this research.
What this research studies
This research focuses on developing a new imaging technique to visualize brain activity in three dimensions at high speeds. By using advanced microscopy methods, the team aims to capture rapid neural signals in a zebrafish model, which can provide insights into how the brain communicates. The approach involves using genetically encoded voltage indicators to record electrical activity across large areas of the nervous system, allowing for a better understanding of neural dynamics. This could lead to breakthroughs in how we study brain function and disorders.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain function and lead to new treatments for neurological disorders.
How similar studies have gone: Other research has shown promise in using advanced imaging techniques for brain studies, but this specific approach is novel and untested.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Yi, Ji — Johns Hopkins University
- Study coordinator: Yi, Ji
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.