High-resolution virome-wide infection analysis in type 1 diabetes birth cohorts
Official title: High-resolution, virome-wide infection analysis in type 1 diabetes birth cohorts
Funded at Translational Genomics Research Inst · NIH-11396343 · Data updated 2026-11-12
Researchers will study viruses over time in babies and young children to understand how infections may relate to developing type 1 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Translational Genomics Research Inst NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,029,312 |
| NIH project number | 5R01DK140795-03 |
| Project ID | NIH-11396343 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children enrolled in birth cohorts like TEDDY and ENDIA who have or are at risk for type 1 diabetes.
✕Less likely to help
Children outside these specific birth cohorts or without risk factors for type 1 diabetes.
What this research studies
This project uses a cutting-edge, long-term analysis of viral exposures in children from birth cohorts to uncover links between infections and type 1 diabetes risk. It will apply PepSeq, a highly multiplexed serology technology, to map viruses over time in the TEDDY and ENDIA cohorts. The goal is to reveal viral exposure patterns that could inform prevention strategies for those at high risk. The study focuses on a real-world pediatric population and leverages existing longitudinal data to explore potential causal clues.
Why it matters
Potential benefit: If successful, findings could guide prevention efforts and early interventions for children at risk of type 1 diabetes.
How similar studies have gone: Prior large studies have suggested viral associations with T1D but lacked high-resolution, longitudinal viral analyses; this project represents a novel, more detailed approach.
Where this research is happening
-
Translational Genomics Research Inst
Phoenix, United States Active
Researchers
- Principal investigator: Altin, John — Translational Genomics Research Inst
- Study coordinator: Altin, John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.