HBV cure research in people living with HIV or HBV
Official title: Clinical Project
Funded at Johns Hopkins University · NIH-11600325 · Data updated 2026-11-12
Researchers at Johns Hopkins are studying how hepatitis B virus persists in people with HIV or HBV to help move toward a functional cure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 17, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $2,218 |
| NIH project number | 3U19AI188551-02S4 |
| Project ID | NIH-11600325 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are adults living with HIV and/or HBV who have well-characterized clinical status and are enrolled for longitudinal plasma analysis.
✕Less likely to help
Patients who do not have HBV or HIV or who cannot provide longitudinal plasma samples may not benefit directly.
What this research studies
This project looks at HBV behavior in the blood of people who already have HIV or HBV. By measuring virus pieces, proteins, DNA, and RNA in plasma over time, researchers aim to understand how HBV replication and the body's immune response change with treatment. They will use serologic and molecular markers and build mathematical models to explain how treatments affect HBV decay and to identify factors that influence cure chances. The study links HIV treatment effects with HBV dynamics to improve strategies for curing HBV in co-infected patients.
Why it matters
Potential benefit: If successful, the work could inform new treatment strategies that lead to a functional cure for HBV in people living with HIV/HBV.
How similar studies have gone: Previous studies have shown that detailed viral and immune profiling can reveal drivers of HBV persistence, supporting this approach.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Thio, Chloe L — Johns Hopkins University
- Study coordinator: Thio, Chloe L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.