HBV cure insights in people living with HIV or HBV
Official title: Clinical Project
Funded at Johns Hopkins University · NIH-11600459 · Data updated 2026-11-12
A Johns Hopkins team is studying how hepatitis B virus behaves in the blood of people with HIV or HBV to move toward a functional cure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 17, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $88,488 |
| NIH project number | 3U19AI188551-02S3 |
| Project ID | NIH-11600459 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are adults living with HIV and/or HBV who have well-characterized clinical data and consent to blood-based measurements of HBV and host responses.
✕Less likely to help
Participants whose HBV dynamics do not align with the study’s models or who cannot tolerate serial blood sampling may see limited direct benefit.
What this research studies
This project analyzes blood samples over time to map how HBV replicates and how the immune system responds in people who also have HIV or HBV. By measuring viral proteins, DNA, and RNA, researchers hope to uncover patterns that explain why HBV persists and how treatments influence these patterns. The work uses a comprehensive panel of blood tests and mathematical models to tie viral behavior to liver disease markers and treatment effects. The study aims to translate these findings into clearer targets for curing HBV in co-infected individuals.
Why it matters
Potential benefit: If successful, the research could inform better strategies to achieve a functional cure for HBV in people living with HIV or HBV.
How similar studies have gone: Previous work has shown that detailed plasma markers can reveal HBV dynamics, supporting the potential for this approach to yield actionable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Thio, Chloe L — Johns Hopkins University
- Study coordinator: Thio, Chloe L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.