Glycosylation changes that boost heart signals and lead to heart failure
Official title: Reduced Complex N-Glycosylation, β-Adrenergic Receptor Sensitivity, and Heart Failure
Funded at Wright State University · NIH-11445090 · Data updated 2026-11-12
A study to understand how changes in sugar attachments on heart cell receptors may fuel heart failure, with potential to guide new treatments.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wright State University NIH-funded |
| Lab location | 1 site (Dayton, United States) |
| Project start | August 15, 2026 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $552,338 |
| NIH project number | 1R15HL188532-01 |
| Project ID | NIH-11445090 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with heart failure or individuals at risk could benefit from future therapies derived from this work.
✕Less likely to help
Direct patient benefit is unlikely for healthy individuals or those outside the heart failure spectrum.
What this research studies
In people with heart failure, excessive signaling through the heart’s beta-adrenergic receptors can worsen the condition. This project tests whether a specific alteration in cell-surface sugar structures, called complex N-glycosylation, makes these receptors overactive and drives early problems in heart cells. Researchers will use models that mimic human heart biology to see how reduced glycosylation affects calcium signaling, heart muscle contraction, and energy balance. If the link is confirmed, it could point to new ways to prevent or slow heart failure by targeting these glycosylation pathways.
Why it matters
Potential benefit: Understanding this mechanism could lead to new strategies to prevent or slow heart failure by modifying receptor signaling.
How similar studies have gone: Initial data in models suggest that glycosylation changes can influence β1-AR signaling, with ongoing studies to confirm translational relevance.
Where this research is happening
-
Wright State University
Dayton, United States Active
Researchers
- Principal investigator: Bennett, Eric S — Wright State University
- Study coordinator: Bennett, Eric S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.