Genomics Core: Genetic Mouse Models and Transcriptome Analysis for Cardiovascular Research
Official title: Core C: Genomics Core
Funded at Medical College of Wisconsin · NIH-11420075 · Data updated 2026-11-12
A genomics core at a major university provides mouse genetic models and advanced RNA sequencing to support cardiovascular research projects.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | September 1, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $234,243 |
| NIH project number | 1P01HL180287-01A1 |
| Project ID | NIH-11420075 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals whose cardiovascular research could be modeled or understood through transgenic mice and genomic analyses.
✕Less likely to help
Patients not involved in genetic or transcriptomic cardiovascular research may see limited direct benefit.
What this research studies
This grant funds a Genomics Core that uses genetically modified mice as a key experimental platform. It will breed, genotype, and ensure quality of transgenic and knockout animals, and create new mouse models using CRISPR-Cas9 or BAC recombineering. The core will also perform global and single-cell transcriptome analyses, with tailored bioinformatics for RNA sequencing data. Researchers across several projects will rely on the core for genome-wide expression studies and data interpretation.
Why it matters
Potential benefit: If successful, patients could benefit from faster development of genetically informed cardiovascular therapies and models that mirror human disease.
How similar studies have gone: Previous genomics cores have enabled rapid creation of disease-relevant mouse models and comprehensive RNA-seq analyses, with strong track records in similar programs.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Geurts, Aron M — Medical College of Wisconsin
- Study coordinator: Geurts, Aron M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.