Genome-based tests to map, monitor, and manage insecticide resistance in malaria mosquitoes
Official title: Genome-based diagnostics for mapping, monitoring and management of insecticide resistance in major African malaria vectors
Funded at Tmliverpool School of Tropical Medicine · NIH-11386684 · Data updated 2026-11-12
Aimed at improving how we detect and respond to insecticide resistance in African malaria-carrying mosquitoes to protect people and travelers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tmliverpool School of Tropical Medicine NIH-funded |
| Lab location | 1 site (Liverpool, United Kingdom) |
| Project start | February 15, 2016 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $462,627 |
| NIH project number | 5R01AI116811-10 |
| Project ID | NIH-11386684 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals living in malaria-endemic regions or deployed personnel who could benefit from improved vector control and reduced malaria risk.
✕Less likely to help
Those not exposed to malaria risk or in areas without vector control programs may have limited direct benefit.
What this research studies
This grant focuses on understanding how malaria mosquitoes in Africa develop resistance to insecticides and on creating genome-based tools to map and monitor these changes. Researchers will leverage the world’s largest vector genomics resource to identify resistance variants and validate them for practical use in control programs. The work is oriented toward real-world applications that help mosquito-control managers decide when to switch interventions to keep malaria in check. The project prioritizes East Africa and involves collaboration with field programs and trials to link genetic findings with epidemiological outcomes.
Why it matters
Potential benefit: If successful, this work could lead to smarter mosquito-control strategies that keep insecticides effective longer and reduce malaria risk for people in Africa and travelers.
How similar studies have gone: Previous vector-genomics work has shown that identifying resistance variants can guide control strategies, with ongoing efforts expanding genomic catalogs of resistance.
Where this research is happening
-
Tmliverpool School of Tropical Medicine
Liverpool, United Kingdom Active
Researchers
- Principal investigator: Donnelly, Martin James — Tmliverpool School of Tropical Medicine
- Study coordinator: Donnelly, Martin James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.