Genetics of secretion in yeast
Funded at University of California, San Diego · NIH-11518844 · Data updated 2026-11-12
Researchers are studying how yeast cells move and break down parts of their internal plumbing (ER) to recycle materials, which could reveal new biology about cellular housekeeping.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | July 1, 1985 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $21,343 |
| NIH project number | 3R01GM035370-41S1 |
| Project ID | NIH-11518844 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients; involves yeast and cell models.
✕Less likely to help
No direct patient benefits expected in this yeast-focused study.
What this research studies
This project looks at how actin structures at contact points between the cortical ER and endocytic pits influence autophagy in yeast. It aims to test whether deleting ER-plasma membrane tether genes can bypass the need for actin in ER-phagy and whether this bypass applies to other autophagy pathways. The team plans to compare yeast results with human cell approaches using siRNA to explore potential conservation of the mechanism. Findings could improve our understanding of how cells regulate waste processing and membrane dynamics.
Why it matters
Potential benefit: Understanding fundamental cellular recycling could inform disease research related to protein aggregation and autophagy.
How similar studies have gone: Prior work suggests a conserved mechanism between yeast and mammalian cells in autophagy, supporting relevance but details are still being explored.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Novick, Peter Jay — University of California, San Diego
- Study coordinator: Novick, Peter Jay
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.