Genetics of IgA nephropathy through network-based genetic links
Official title: Genetics of IgA nephropathy by integrative network-based association studies
Funded at Columbia University Health Sciences · NIH-11393618 · Data updated 2026-11-12
A study to understand why some people develop IgA nephropathy by looking at how our genes and immune system networks contribute to the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 17, 2015 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $652,967 |
| NIH project number | 5R01DK105124-09 |
| Project ID | NIH-11393618 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with IgA nephropathy or related kidney conditions, particularly those with a genetic or familial risk profile.
✕Less likely to help
Patients without IgA nephropathy or related kidney disease may not directly benefit.
What this research studies
This project analyzes genetic data from thousands of people to uncover how different genes and immune pathways come together to cause IgA nephropathy. Researchers will integrate multiple genetic studies and serum markers to find causal genes and potential drug targets. The work builds on previous findings that connect mucosal IgA responses with kidney injury, aiming to translate genetic insights into better understanding and treatment options for patients. The study is focused on humans and uses patient-derived data and large-scale genomic analyses to map disease mechanisms.
Why it matters
Potential benefit: If successful, the research could reveal new targets for therapies to slow or stop kidney damage in patients with IgA nephropathy.
How similar studies have gone: Previous genetic studies have identified several risk loci; this project aims to connect those findings to functional genes and pathways, representing a progression from discovery to potential targets.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Kiryluk, Krzysztof — Columbia University Health Sciences
- Study coordinator: Kiryluk, Krzysztof
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.