Genetic drivers of IgA (Berger's) kidney disease
Genetics of IgA nephropathy by integrative network-based association studies
This project looks for gene changes that make people more likely to get IgA (Berger's) kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11121895 on NIH RePORTER |
What this research studies
Researchers are analyzing genetic and blood data from thousands of people with IgA nephropathy, related IgA vasculitis, and healthy controls. They combine large-scale genome-wide scans, measurements of serum IgA and galactose-deficient IgA1, and network-based methods to find which genes are most likely to cause disease. The team uses statistical approaches such as Mendelian randomization and integrative network analyses to prioritize causal genes and biological pathways. Findings may point to biomarkers and existing or new drug targets that could help people with Berger's disease.
Who could benefit from this research
Good fit: People diagnosed with IgA nephropathy (Berger's) or IgA vasculitis who are willing to provide a blood sample and medical records are the typical candidates.
Not a fit: People without IgA-related kidney disease or those seeking immediate changes in their medical care are unlikely to get direct benefit from this genetics-focused work.
Why it matters
Potential benefit: Could reveal genes and pathways that lead to better risk tests and new targeted treatments for Berger's disease.
How similar studies have performed: Large prior GWAS have already found many risk loci and links to IgA levels, so this work builds on established findings while applying newer network methods.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Kiryluk, Krzysztof — Columbia University Health Sciences
- Study coordinator: Kiryluk, Krzysztof
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.