Gangliosides and Alzheimer’s: how fats influence amyloid clumps in Alzheimer’s disease
Official title: Investigation the Roles of Gangliosides in Amyloid Aggregation Associated with Alzheimer’s Disease
Funded at Florida State University · NIH-11432596 · Data updated 2026-11-12
A gamma-amyloid project at Florida State University looks at how brain fats called gangliosides affect the formation and spread of harmful amyloid clumps in Alzheimer’s disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project start | September 1, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $443,060 |
| NIH project number | 1R01AG103065-01 |
| Project ID | NIH-11432596 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with or at risk for Alzheimer’s disease who may benefit from future therapies targeting amyloid pathways.
✕Less likely to help
Participants without Alzheimer’s pathology or those not affected by brain lipid interactions may see no direct benefit.
What this research studies
This project studies how specific brain lipids influence the way amyloid-beta proteins clump together, spread, and damage brain cells. It uses a mix of lab techniques, including advanced NMR methods and cell-based tests, to understand the shapes of lipid-assisted amyloid aggregates. The goal is to connect lipid composition with different toxic forms and disease-related brain changes from a patient perspective. If successful, the work could point to new angles for therapies aimed at reducing toxic amyloid forms.
Why it matters
Potential benefit: If the approach succeeds, it could lead to new strategies to slow or prevent brain damage in people with Alzheimer’s disease.
How similar studies have gone: Previous studies show that lipid environments can influence amyloid aggregation, but this project aims to define specific lipid-amyloid relationships and their toxic consequences.
Where this research is happening
-
Florida State University
Tallahassee, United States Active
Researchers
- Principal investigator: Ramamoorthy, Ayyalusamy — Florida State University
- Study coordinator: Ramamoorthy, Ayyalusamy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.