FoxA1/2 regulation in human liver formation
Official title: Regulating FoxA-Mediated Transcription during Liver Development
Funded at Medical College of Wisconsin · NIH-11446173 · Data updated 2026-11-12
A study to understand how FoxA1 and FoxA2 control the first steps of human liver development and how their activity is regulated.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $406,985 |
| NIH project number | 1R01DK145591-01A1 |
| Project ID | NIH-11446173 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not a patient-enrolling study; findings may ultimately benefit people with liver conditions by informing new approaches.
✕Less likely to help
This basic science project does not involve direct patient participation.
What this research studies
This project looks at how the liver-creating factors FoxA1 and FoxA2 open chromatin to start liver gene programs in humans. Researchers will explore how these pioneer factors interact with co-activators to regulate chromatin and initiate hepatic fate. The work uses human cellular models to map when and how FoxA1/2 regulate target genes during liver specification. Findings could illuminate fundamental processes of liver development and potential targets for liver-related diseases. The grant supports experiments from 2026 through 2030 at the Medical College of Wisconsin under PI Lisa A. Cirillo.
Why it matters
Potential benefit: Understanding early liver development could inform future therapies for liver diseases and congenital liver disorders.
How similar studies have gone: Previous work shows FoxA factors shape chromatin and influence liver gene programs, but direct human hepatic-specification regulation remains to be clarified.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Cirillo, Lisa a — Medical College of Wisconsin
- Study coordinator: Cirillo, Lisa a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.