Fluorination strategies to make new medicinal compounds
Official title: Fluorination and Fluoroalkylation Strategies for Synthetic and Medicinal Chemistry
Funded at Purdue University · NIH-11384236 · Data updated 2026-11-12
This grant supports developing new chemical methods to add fluorine to molecules, which can help create better medicines and biological tools.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | August 1, 2017 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $407,911 |
| NIH project number | 5R35GM124661-11 |
| Project ID | NIH-11384236 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patient participation; this is a basic chemistry project.
✕Less likely to help
Patients are unlikely to participate directly in this project as it focuses on chemical method development in the lab.
What this research studies
Researchers at Purdue University are working on new ways to introduce fluorine into organic molecules under mild conditions. The goal is to overcome challenges fluorinated substrates pose and to access fluorinated building blocks that are important for drug design and biological probes. The work uses innovative approaches like electrochemistry and metal-catalyzed reactions to enable selective fluorination and fluoroalkylation. This could streamline the synthesis of potential therapeutics and improve our understanding of how fluorinated compounds behave in biology. Results could impact how drugs are developed and studied in the lab.
Why it matters
Potential benefit: If successful, this research could speed the creation of new fluorinated drugs and imaging tools with better properties.
How similar studies have gone: Prior fluorination chemistry work has shown promise in enabling access to useful medicinal scaffolds, though this program emphasizes new catalytic and electrochemical strategies.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Altman, Ryan a — Purdue University
- Study coordinator: Altman, Ryan a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.