Finding new small molecule drugs using advanced database techniques
Official title: Discovering novel small molecule drugs through tandem mass spectral database search
Funded at Chemia Biosciences, INC. · NIH-10695838 · Data updated 2026-11-12
This study is looking for new natural medicines by using advanced technology to explore plants and microbes, hoping to find fresh treatments that could help people with various health conditions.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Chemia Biosciences, INC. NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $275,484 |
| NIH project number | 1R43GM150301-01 |
| Project ID | NIH-10695838 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who may benefit from new antibiotic or antifungal treatments, particularly those with resistant infections.
✕Less likely to help
Patients who are not suffering from infections or conditions that require antibiotic or antifungal treatments may not benefit from this research.
What this research studies
This research aims to discover novel small molecule drugs derived from natural products by integrating genome mining with computational metabolomics. It utilizes advanced techniques such as high throughput tandem mass spectrometry to analyze complex datasets from microbial and plant species. By developing new computational tools, the project seeks to identify previously overlooked natural products that could lead to effective new therapies. This approach addresses the limitations of current methods that often rediscover known molecules.
Why it matters
Potential benefit: If successful, this research could lead to the development of new and effective drugs for various conditions, enhancing treatment options for patients.
How similar studies have gone: While the approach of integrating genome mining with computational metabolomics is innovative, similar methodologies have shown promise in other areas of drug discovery.
Where this research is happening
-
Chemia Biosciences, INC.
Pittsburgh, United States Active
Researchers
- Principal investigator: Behsaz, Bahar — Chemia Biosciences, INC.
- Study coordinator: Behsaz, Bahar
Related research
Other NIH-funded projects on the same topics.
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Discovering new natural products from fungi for better medicines
A funding-supported project uses computer and lab tools to find new antimicrobial compounds made by fungi that could become the antibiotics of tomorrow.
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A new platform to discover natural product molecules
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-
Finding new natural antibiotics to fight resistant infections
This study is looking for new natural antibiotics to help fight infections that are becoming harder to treat because of antibiotic resistance, and it's for anyone who might be affected by these tough-to-treat infections.
-
Finding new antibiotics from fungi
This study is looking for new natural antibiotics from fungi to help fight infections that don't respond to regular treatments, and it's for anyone concerned about antibiotic resistance.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.