Finding different types of overactive bladder
Official title: Predicting phenotypes in benign urology
Funded at Duke University · NIH-11235141 · Data updated 2026-11-12
Combining symptom information and lab data from people with urinary urgency, frequency, or nighttime urination to find distinct types of overactive bladder so treatments can better match each person.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | February 1, 2024 |
| Project end | November 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $661,506 |
| NIH project number | 5R01DK138121-03 |
| Project ID | NIH-11235141 on NIH RePORTER |
Who could benefit from this research
✓Could help
People who have urinary urgency, frequency, nocturia, or urgency incontinence (typical symptoms of overactive bladder) would be the relevant group for this research.
✕Less likely to help
People whose urinary symptoms are due to clearly identified causes such as neurological disease, infection, or anatomical obstruction may not benefit from these subtype findings.
What this research studies
This project uses information from large groups of people who already enrolled in pelvic pain and lower urinary tract symptom studies (MAPP and LURN). Researchers will add biological test results from stored blood and tissue samples to the symptom data. Computer algorithms and clustering methods will look for patterns that separate people into meaningful subgroups. The goal is to link those subgroups to likely treatment responses so care can be more personalized.
Why it matters
Potential benefit: If successful, this work could help doctors choose treatments that are more likely to work for each type of overactive bladder.
How similar studies have gone: Previous work grouped patients by symptoms using clustering methods, but adding biological data from stored specimens is a newer step that has not been fully tested.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Siddiqui, Nazema Y — Duke University
- Study coordinator: Siddiqui, Nazema Y
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.