Fibrinogen’s role in Alzheimer's disease and brain blood flow
Official title: Role of Fibrinogen in Alzheimer's Disease
Funded at Rockefeller University · NIH-11377718 · Data updated 2026-11-12
This grant investigates how a blood protein called fibrinogen interacts with beta-amyloid to influence brain blood flow and neuron survival in Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2018 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $771,522 |
| NIH project number | 5R01NS106668-09 |
| Project ID | NIH-11377718 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with Alzheimer's disease or related cognitive impairment, or those at risk, could benefit from future therapies targeting the Aβ–fibrinogen interaction.
✕Less likely to help
If your condition is not related to Alzheimer's disease or vascular factors, this study would not directly benefit you.
What this research studies
People with Alzheimer's disease often have changes in brain blood vessels that may worsen cognitive problems. The project looks at how beta-amyloid, a key Alzheimer’s molecule, binds to fibrinogen to form abnormal blood clots that resist breakdown and may damage brain tissue. By studying these interactions in brain tissue and models, researchers aim to uncover how vascular problems contribute to dementia. This work builds on two decades of prior findings and explores whether different forms of beta-amyloid alter toxicity through their interaction with fibrinogen.
Why it matters
Potential benefit: Understanding this mechanism could lead to new therapies that improve brain blood flow or reduce clot-related damage in Alzheimer's.
How similar studies have gone: Prior work has shown the Aβ–fibrinogen interaction contributes to abnormal clots and neuronal toxicity, supporting potential translational relevance.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Norris, Erin H. — Rockefeller University
- Study coordinator: Norris, Erin H.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.