Exploring molecular pathways linked to diabetic retinopathy
Integrative multi-omics for discovery of molecular pathways associated with diabetic retinopathy
This study is looking at how genes and other biological factors affect diabetic retinopathy, an eye condition that can cause vision loss, especially in Hispanic and Latino people, by analyzing blood samples to find clues that could help improve prevention and treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11171678 on NIH RePORTER |
What this research studies
This research investigates the genetic and molecular factors associated with diabetic retinopathy (DR), a serious eye condition that can lead to blindness, particularly in Hispanic and Latino populations. By analyzing blood samples from participants with varying degrees of diabetes and DR, the study aims to identify specific biomarkers and genetic variants that contribute to the disease. The research will utilize advanced techniques to measure transcript and metabolite levels, providing insights into the underlying mechanisms of DR. This approach seeks to enhance our understanding of how these factors interact and may lead to improved prevention and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation include Hispanic and Latino individuals with Type 2 diabetes, particularly those with varying levels of diabetic retinopathy.
Not a fit: Patients who do not have diabetes or those without any risk factors for diabetic retinopathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies and diagnostic tools for diabetic retinopathy, potentially reducing the risk of blindness in affected populations.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for diabetic retinopathy, but this study aims to fill gaps in representation and understanding of the disease mechanisms, making it a novel approach.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Padovani-Claudio, Dolly Ann — Vanderbilt University Medical Center
- Study coordinator: Padovani-Claudio, Dolly Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.