Exploring molecular pathways linked to diabetic retinopathy
Official title: Integrative multi-omics for discovery of molecular pathways associated with diabetic retinopathy
Funded at Vanderbilt University Medical Center · NIH-11171678 · Data updated 2026-11-12
This study is looking at how genes and other biological factors affect diabetic retinopathy, an eye condition that can cause vision loss, especially in Hispanic and Latino people, by analyzing blood samples to find clues that could help improve prevention and treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | September 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $741,232 |
| NIH project number | 5R01EY036258-02 |
| Project ID | NIH-11171678 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include Hispanic and Latino individuals with Type 2 diabetes, particularly those with varying levels of diabetic retinopathy.
✕Less likely to help
Patients who do not have diabetes or those without any risk factors for diabetic retinopathy may not benefit from this research.
What this research studies
This research investigates the genetic and molecular factors associated with diabetic retinopathy (DR), a serious eye condition that can lead to blindness, particularly in Hispanic and Latino populations. By analyzing blood samples from participants with varying degrees of diabetes and DR, the study aims to identify specific biomarkers and genetic variants that contribute to the disease. The research will utilize advanced techniques to measure transcript and metabolite levels, providing insights into the underlying mechanisms of DR. This approach seeks to enhance our understanding of how these factors interact and may lead to improved prevention and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies and diagnostic tools for diabetic retinopathy, potentially reducing the risk of blindness in affected populations.
How similar studies have gone: Previous research has shown promise in identifying biomarkers for diabetic retinopathy, but this study aims to fill gaps in representation and understanding of the disease mechanisms, making it a novel approach.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Padovani-Claudio, Dolly Ann — Vanderbilt University Medical Center
- Study coordinator: Padovani-Claudio, Dolly Ann
Related research
Other NIH-funded projects on the same topics.
-
Integrative multi-omics to understand diabetic retinopathy
A doctor-scientist team will study blood markers and genetic signals to see why diabetic retinopathy happens and how it affects Hispanic/Latino people.
-
Smartphone retinal imaging for diabetic eye disease in Egypt
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Retinal Cell Loss in Diabetic Retinopathy
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Redox-triggered REDD1 blockers for diabetic retinopathy
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Ultrafast eye imaging to detect and track diabetic retinopathy
A doctor-science team is developing ultra-fast eye scans to better see tiny blood vessels in people with diabetic retinopathy, helping catch changes early and guide treatment.
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Practical device to automatically track abnormal retinal blood vessel growth in diabetic eye disease
A new, easier-to-use imaging device aims to automatically detect and monitor abnormal retinal blood vessel growth in people with diabetic retinopathy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.