Exploring how specific spinal neurons process pain signals
Official title: Understanding the functional anatomy of nociceptive spinal output neurons
Funded at University of Pittsburgh at Pittsburgh · NIH-10982449 · Data updated 2026-11-12
This study is looking at how certain nerve cells in the spinal cord send pain signals to the brain, which could help us find better ways to manage chronic pain for people who suffer from it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31NS134315-02 |
| Project ID | NIH-10982449 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic pain conditions who may benefit from new pain management strategies.
✕Less likely to help
Patients with acute pain or those not experiencing chronic pain may not receive direct benefits from this research.
What this research studies
This research investigates the role of spinal projection neurons in transmitting pain signals from the spinal cord to the brain. By using advanced techniques like viral tracing and two-photon imaging, the study aims to understand how different groups of these neurons function and their specific contributions to pain perception. The research will also assess the behavioral responses associated with these neurons, providing insights into their roles in pain management. This comprehensive approach could lead to new strategies for treating chronic pain conditions.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for managing chronic pain more effectively.
How similar studies have gone: Previous research has shown promise in understanding pain mechanisms through similar anatomical and functional approaches, indicating potential for success in this area.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Bleimeister, Isabel — University of Pittsburgh at Pittsburgh
- Study coordinator: Bleimeister, Isabel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.