Exploring how oxidative stress affects aging through proteasome function
Official title: Harnessing Redox Regulation of Proteasome Function to Promote Healthy Aging
Funded at Harvard School of Public Health · NIH-10983419 · Data updated 2026-11-12
This study is looking at how certain molecules that can cause stress in our cells might affect the aging process by changing proteins that help our cells work properly, using tiny worms as a model to learn more about healthy aging.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard School of Public Health NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 9, 2024 |
| Project end | August 8, 2027 |
| Funding year | 2024 |
| Award (this year) | $79,756 |
| NIH project number | 1F32AG085703-01A1 |
| Project ID | NIH-10983419 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the biological mechanisms of aging and those who may be affected by age-related conditions.
✕Less likely to help
Patients with acute conditions unrelated to aging or oxidative stress may not benefit from this research.
What this research studies
This research investigates the role of reactive oxygen species in the aging process by examining how they modify proteins involved in cellular function. Using advanced proteomic techniques, the study will analyze changes in cysteine oxidation in the proteasome of the model organism C. elegans as it ages. The goal is to understand how these modifications impact proteasome activity and longevity, potentially leading to new insights into healthy aging. By identifying specific regulatory cysteines, the research aims to link oxidative stress to age-related changes in cellular function.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting healthy aging and improving longevity.
How similar studies have gone: Previous research has shown promising results in understanding the role of oxidative stress in aging, but this approach is novel in its focus on proteasome function.
Where this research is happening
-
Harvard School of Public Health
Boston, United States Active
Researchers
- Principal investigator: Morrow, Christopher Scott — Harvard School of Public Health
- Study coordinator: Morrow, Christopher Scott
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.