Exploring how neural crest cells move during embryo development
Official title: Rapid non-invasive biomechanical imaging of neural crest cell migration in vivo
Funded at Wayne State University · NIH-10811154 · Data updated 2026-11-12
This study is looking at how certain cells in developing embryos move and react to their surroundings, using a special imaging technique to get clear pictures of these cells in action, which could help us understand and improve treatments for birth defects.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | September 18, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $329,862 |
| NIH project number | 1R21HD112663-01A1 |
| Project ID | NIH-10811154 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with congenital malformations or hereditary diseases related to neural crest cell development.
✕Less likely to help
Patients with conditions unrelated to neural crest cell migration or those who are not affected by congenital malformations may not benefit from this research.
What this research studies
This research investigates the movement of neural crest cells (NCCs) during the development of embryos, particularly focusing on how these cells respond to mechanical changes in their environment. Using a novel imaging technology called Brillouin microscopy, the researchers aim to create detailed images of NCCs and their surrounding tissues in real-time. This non-invasive approach will help to understand the biomechanics involved in critical processes like cell migration and organ formation, which are essential for healthy development. By addressing the complexities of NCC behavior, the study seeks to uncover fundamental mechanisms that could lead to better understanding and treatment of congenital malformations.
Why it matters
Potential benefit: If successful, this research could lead to improved insights into congenital disorders linked to neural crest cell development, potentially informing new therapeutic strategies.
How similar studies have gone: While the approach of using Brillouin microscopy is relatively novel, similar studies have shown promise in understanding cell behavior through biomechanical imaging techniques.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Zhang, Jitao — Wayne State University
- Study coordinator: Zhang, Jitao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.