Exploring how Myosin 5b affects liver metabolism
Official title: Understanding the role of Myosin 5b in liver metabolism
Funded at Medical University of South Carolina · NIH-11084483 · Data updated 2026-11-12
This study is looking at a protein called Myosin 5b to see how it helps liver cells manage important substances like fats and sugars, which could help people with liver-related health issues understand their condition better.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | May 15, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $113,250 |
| NIH project number | 5R03DK139282-02 |
| Project ID | NIH-11084483 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with liver metabolism disorders or congenital conditions like Microvillus Inclusion Disease.
✕Less likely to help
Patients with unrelated liver conditions or those without metabolic disorders may not receive direct benefits from this research.
What this research studies
This research investigates the role of Myosin 5b, a protein involved in transporting essential molecules within liver cells. By studying mice that lack Myosin 5b, researchers aim to understand how this protein influences liver function, particularly in relation to lipid and glycogen storage, as well as mitochondrial activity. The study will utilize advanced techniques to analyze liver metabolism and the cellular processes affected by Myosin 5b. Patients with conditions related to liver metabolism may benefit from insights gained through this research.
Why it matters
Potential benefit: If successful, this research could lead to new understanding and treatments for liver-related metabolic disorders.
How similar studies have gone: Previous research has shown promising results in understanding the role of similar proteins in liver function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Engevik, Amy C — Medical University of South Carolina
- Study coordinator: Engevik, Amy C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.