Exploring how genetic differences affect gene expression in diverse populations
Official title: Uncovering sources of human gene expression variation in a globally diverse cohort
Funded at Johns Hopkins University · NIH-10773040 · Data updated 2026-11-12
This study is looking at how differences in our genes can affect how our bodies use those genes, which might play a role in our health, and it's for anyone interested in understanding how genetics can impact health in different communities.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 1, 2023 |
| Project end | September 26, 2025 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31HG012900-02 |
| Project ID | NIH-10773040 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals from diverse ethnic backgrounds who are interested in understanding the genetic factors that may affect their health.
✕Less likely to help
Patients with no genetic variation or those from very homogenous populations may not benefit from this research.
What this research studies
This research investigates how variations in human genes influence gene expression levels and splicing, which can impact health and disease. By analyzing gene expression data alongside genetic information from a globally diverse group of individuals, the study aims to identify the genetic variants responsible for these differences. The researchers will develop a new method to account for local genetic relationships among individuals, improving the accuracy of their findings. This approach seeks to enhance the understanding of genetic diversity and its implications for health outcomes across different populations.
Why it matters
Potential benefit: If successful, this research could lead to more accurate identification of genetic factors influencing health, benefiting personalized medicine approaches.
How similar studies have gone: Previous research has shown that controlling for population structure in genetic studies can reduce errors, indicating a promising avenue for this novel approach.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Taylor, Dylan James — Johns Hopkins University
- Study coordinator: Taylor, Dylan James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.