Exploring how essential genes affect aging
Official title: Understanding of Essential Gene Function in Aging
Funded at University of Virginia · NIH-11287448 · Data updated 2026-11-12
This study is looking at how certain important genes affect aging by testing them in tiny organisms like yeast and worms, and it hopes to find clues that could help us understand how these genes might influence how we age as humans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | July 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $342,208 |
| NIH project number | 7R01AG079944-02 |
| Project ID | NIH-11287448 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the biological mechanisms of aging and those with age-related health concerns.
✕Less likely to help
Patients with acute conditions unrelated to aging or genetic factors may not benefit from this research.
What this research studies
This research investigates the role of essential genes in the aging process by utilizing advanced genetic techniques in model organisms like yeast and worms. By systematically knocking out genes and observing the effects on lifespan, the study aims to identify conserved genetic pathways that influence aging across different species, including humans. The findings could provide insights into how certain genes may regulate longevity and contribute to age-related changes in cellular function.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting healthy aging and potentially extending lifespan in humans.
How similar studies have gone: Previous research has shown promising results in understanding genetic influences on aging, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Kaya, Alaattin — University of Virginia
- Study coordinator: Kaya, Alaattin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.