Exploring how creatine kinase affects asthma in patients
Official title: Determining the Role of Creatine Kinase in Asthma
Funded at University of Arizona · NIH-10873669 · Data updated 2026-11-12
This study is looking at a special enzyme called creatine kinase to see how it might help us understand which kids with asthma might have problems as they grow up, so we can find better ways to manage and treat their condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | June 22, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $191,875 |
| NIH project number | 5R21AI178782-02 |
| Project ID | NIH-10873669 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with asthma, particularly those who may experience persistent symptoms into adulthood.
✕Less likely to help
Patients who do not have asthma or who are not children may not receive any benefit from this research.
What this research studies
This research investigates the role of creatine kinase, an enzyme important for energy balance in cells, in the context of asthma, particularly focusing on childhood asthma that may persist into adulthood. The study aims to identify biomarkers and prediction models that can help understand which children are at risk of developing long-term asthma issues. By examining serum levels and gene expression of creatine kinase in patients, the researchers hope to uncover insights that could lead to better management and treatment strategies for asthma. The approach includes both observational studies and experimental models to assess the enzyme's behavior in response to allergens.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for predicting and managing asthma in children, potentially reducing the long-term impact of the disease.
How similar studies have gone: Previous studies have indicated a potential link between creatine kinase levels and asthma, suggesting that this research could build on promising findings, although the specific approach may be novel.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Ledford, Julie Gunnells — University of Arizona
- Study coordinator: Ledford, Julie Gunnells
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.