Exploring how cancer cells struggle with DNA replication
Understanding and targeting the DNA replication stress in cancer cells
This study is looking at the problems cancer cells have when copying their DNA, which can make them unstable, and aims to find ways to target these weaknesses for better treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10652612 on NIH RePORTER |
What this research studies
This research investigates the challenges cancer cells face during DNA replication, known as replication stress, which can lead to genomic instability. By understanding the molecular mechanisms behind this stress, the research aims to identify specific vulnerabilities in cancer cells that can be targeted for therapy. The approach involves studying the ATR checkpoint pathway, a key regulator of the replication stress response, to uncover how different oncogenic events affect DNA replication. This knowledge could lead to new treatment strategies that exploit these vulnerabilities in cancer therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with various types of cancer who may have underlying issues with DNA replication and genomic instability.
Not a fit: Patients with non-cancerous conditions or those whose cancers do not exhibit replication stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative cancer treatments that specifically target the weaknesses in cancer cells caused by DNA replication stress.
How similar studies have performed: Previous research has shown promising results in targeting replication stress in cancer cells, particularly with the use of PARP inhibitors in BRCA mutant tumors, indicating that this approach has potential for success.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Zou, Lee — Duke University
- Study coordinator: Zou, Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.