Exploring how aging factors like protein changes and nutrient sensing affect health.
Official title: Investigating the interplay between hallmarks of aging; protein glycation, nutrient sensing, and senescence
Funded at Buck Institute for Research on Aging · NIH-10901045 · Data updated 2026-11-12
This study is looking at how certain changes in our bodies as we get older, like how proteins behave and how our cells respond to nutrients, can lead to health issues like insulin resistance, helping us find better ways to manage age-related problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Buck Institute for Research on Aging NIH-funded |
| Lab location | 1 site (Novato, United States) |
| Project start | September 30, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $444,220 |
| NIH project number | 1R56AG082819-01 |
| Project ID | NIH-10901045 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related health issues, particularly those with insulin resistance or metabolic disorders.
✕Less likely to help
Patients who are younger and do not have any signs of age-related diseases may not benefit from this research.
What this research studies
This research investigates the connections between three key aspects of aging: protein glycation, nutrient sensing, and cellular senescence. It aims to understand how these factors interact and contribute to age-related diseases, particularly focusing on insulin resistance and its effects on bodily functions. By examining these relationships, the study seeks to uncover how aging impacts different tissues in the body, which could lead to new insights into managing age-related health issues. Patients may benefit from a better understanding of how these processes affect their health as they age.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related diseases, improving overall health in older adults.
How similar studies have gone: Previous research has shown promising results in understanding the role of aging hallmarks in health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Buck Institute for Research on Aging
Novato, United States Active
Researchers
- Principal investigator: Kapahi, Pankaj — Buck Institute for Research on Aging
- Study coordinator: Kapahi, Pankaj
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.