Exploring genetic variations linked to Alzheimer's disease
Alzheimer's disease-linked microRNA Exploration of UTR Polymorphisms (AdmiRE-UP)
This study is looking at how certain tiny changes in our genes might affect the risk and progression of Alzheimer's disease, with the hope that understanding these changes can help develop new ways to treat or slow down the disease for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10391153 on NIH RePORTER |
What this research studies
This research investigates how specific genetic variations, known as single-nucleotide polymorphisms (SNPs), in microRNA target sites may influence the risk and progression of Alzheimer's disease (AD). By focusing on the regulation of key proteins associated with AD, such as amyloid-β and tau, the study aims to identify how these genetic changes can affect the levels of these proteins in the brain. Patients may benefit from insights gained through this research, which could lead to new therapeutic strategies for delaying or treating AD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for Alzheimer's disease or those diagnosed with early-stage Alzheimer's.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new approaches for preventing or treating Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in exploring genetic factors related to Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Lahiri, Debomoy K — Indiana University Indianapolis
- Study coordinator: Lahiri, Debomoy K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.