Exploring genetic links to cognitive disorders using zebrafish models
Integrated multimodal phenotyping of zebrafish models of human cognitive disorders
This study is looking at how genes might affect thinking and learning by using zebrafish to see how changes in their DNA can impact their brain and behavior, with the hope of finding new ways to help people with cognitive disorders.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10950187 on NIH RePORTER |
What this research studies
This research investigates how genetic factors contribute to cognitive disorders by using zebrafish as a model organism. The team will employ advanced genome editing techniques to create specific genetic modifications in zebrafish and then analyze the resulting changes in brain structure and behavior. By utilizing a novel method called MIC-Drop-seq, they will gather extensive data on gene expression and brain morphology, which will help in understanding the relationship between genetics and cognitive function. The ultimate goal is to develop predictive models that could lead to new treatment strategies for cognitive disorders in humans.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research are individuals with neurodevelopmental disorders that have a genetic basis.
Not a fit: Patients with cognitive disorders not linked to genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatment options for individuals with cognitive disorders.
How similar studies have performed: Other research has shown promise in using animal models to link genetic factors to cognitive outcomes, indicating that this approach has potential for success.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Carey, Clayton — University of Utah
- Study coordinator: Carey, Clayton
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.