Exploring circular RNAs in sepsis and organ failure related to aging
Official title: Novel Targets in aging-associated sepsis and organ failure
Funded at Boston University Medical Campus · NIH-10933755 · Data updated 2026-11-12
This study is looking at how special RNA molecules might help us understand and treat sepsis and organ damage in older adults, especially when they get infections, to find better ways to help them recover.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $449,625 |
| NIH project number | 1R21AG087977-01 |
| Project ID | NIH-10933755 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who are at higher risk for pneumonia and infections, particularly those with acute respiratory distress syndrome.
✕Less likely to help
Patients who are younger and do not have a history of severe infections or respiratory distress may not benefit from this research.
What this research studies
This research investigates the role of circular RNAs in sepsis and organ damage, particularly in older adults. It aims to understand how these unique RNA molecules can serve as potential biomarkers and therapeutic targets for conditions like acute respiratory distress syndrome (ARDS). By studying the immune response in aging populations, the research seeks to identify new strategies to improve patient outcomes in those suffering from infections caused by gram-negative bacteria. The approach involves analyzing immune cells from both young and old mice to uncover differences in inflammatory responses.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools and treatments for elderly patients suffering from severe infections and ARDS.
How similar studies have gone: While the role of circular RNAs is a relatively novel area of investigation, previous studies have shown promise in using RNA-based approaches for understanding and treating various diseases.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Jin, Yang — Boston University Medical Campus
- Study coordinator: Jin, Yang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.