Excitation/Inhibition Balance and Brain Networks in Psychosis
Official title: Excitation/Inhibition Balance in Psychosis
Funded at Ohio State University · NIH-11391922 · Data updated 2026-11-12
A study to understand how brain signaling balance and network activity differ in people with psychosis to guide more personalized treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 7, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $2,106,268 |
| NIH project number | 1R01MH141275-01A1 |
| Project ID | NIH-11391922 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals diagnosed with psychosis spectrum disorders who can undergo brain imaging and participate in computational analyses.
✕Less likely to help
Patients without access to brain imaging or who cannot participate in long computational assessments may receive no direct benefit.
What this research studies
This project looks at how imbalances between excitatory and inhibitory signals in the brain relate to network patterns in psychosis on an individual level. Using advanced brain imaging and computational models, researchers aim to create patient-specific “normative” maps of E/I balance and brain connectivity. The team will explore how these brain features relate to symptoms and how they could become targets for precision psychiatry. The work combines brain data, clinical information, and computer methods to move beyond one-size-fits-all approaches.
Why it matters
Potential benefit: If successful, it could lead to personalized targets for treatments and better understanding of why some patients respond differently to therapies.
How similar studies have gone: Other studies have shown that brain network patterns relate to symptoms, but this project emphasizes individual-level models not yet routinely used in care.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Kraguljac, Nina Vanessa — Ohio State University
- Study coordinator: Kraguljac, Nina Vanessa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.