Epithelial matrisome and how drugs move through it
Official title: The epithelial matrisome and drug transport kinetics
Funded at Oregon State University · NIH-11332307 · Data updated 2026-11-12
A researcher is using 3D models and computer tools to see how the tissue that lines organs affects how medicines move and work in the body.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon State University NIH-funded |
| Lab location | 1 site (Corvallis, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $350,253 |
| NIH project number | 5R35GM151254-04 |
| Project ID | NIH-11332307 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients whose therapies rely on drugs crossing epithelial barriers (e.g., oral, nasal, or mucosal formulations) could benefit from improved delivery.
✕Less likely to help
Patients using therapies that do not rely on epithelial barrier crossing or have already optimized delivery may see little change.
What this research studies
This project uses computer simulations together with three-dimensional models of epithelial barriers to study how the extracellular matrix within these barriers changes with external factors. It looks at how such changes influence the delivery and availability of drugs across tissues. By understanding the matrisome—an interconnected network of ECM proteins and related factors—the work aims to tailor drug bioavailability and improve therapeutic delivery through epithelial barriers.
Why it matters
Potential benefit: If successful, it could lead to better-designed medicines with improved delivery across epithelial barriers.
How similar studies have gone: Previous work shows that ECM composition and architecture can influence drug transport, supporting potential benefits of this approach.
Where this research is happening
-
Oregon State University
Corvallis, United States Active
Researchers
- Principal investigator: Fogg, Kaitlin C — Oregon State University
- Study coordinator: Fogg, Kaitlin C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.