Expanding AMR Surveillance in Animals with Hybrid Long-Read Sequencing
Official title: Expanding Vet-LIRN AMR Surveillance Capacity Through Hybrid Long-Read Sequencing at the Oregon Veterinary Diagnostic Laboratory
Funded at Oregon State University · NIH-11528960 · Data updated 2026-11-12
A veterinary lab in Oregon will use a mix of long- and short-read DNA sequencing to map antimicrobial resistance genes in bacterial samples from various animal sources to improve tracking of resistance.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon State University NIH-funded |
| Lab location | 1 site (Corvallis, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $60,000 |
| NIH project number | 1U18FD008942-01 |
| Project ID | NIH-11528960 on NIH RePORTER |
Who could benefit from this research
✓Could help
Animals and animal-associated bacteria are the primary focus; results inform surveillance that can impact human health indirectly through better outbreak prevention.
✕Less likely to help
Direct clinical care for individual patients is not the focus; the benefits are at the population level through improved surveillance.
What this research studies
This project will pair Oxford Nanopore long reads with Illumina short reads to generate complete bacterial genomes, including mobile resistance elements, from about 650 isolates across animals and settings. The effort aims to create a regional AMR baseline and improve understanding of how resistance genes move between animals and potential human exposures. Results will enrich surveillance data at a key veterinary-human health interface and support faster, more accurate outbreak detection and response. The work is conducted at the Oregon State University Vet-LIRN laboratory in Corvallis and will leverage existing diagnostic workflows and data.
Why it matters
Potential benefit: If successful, this approach could enhance detection of resistant bacteria in animals and help prevent transmission to people.
How similar studies have gone: Hybrid sequencing to resolve resistance elements has shown promise in other settings, but this regional improvement is novel for veterinary AMR surveillance.
Where this research is happening
-
Oregon State University
Corvallis, United States Active
Researchers
- Principal investigator: Sanders, Justin L — Oregon State University
- Study coordinator: Sanders, Justin L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.