NIH-funded research R01 grant

Enhancing Intergenerational Heart Health in Nigeria during Pregnancy and Early Life

Official title: ENhancing Intergenerational HeAlth in Nigeria: Peripartum as Critical Life StagE for CardioVascular Health (ENHANCE-CVH)

Funded at Washington University · NIH-11414880 · Data updated 2026-11-12

A study to test a family-focused program that promotes healthy eating and active living for pregnant women with obesity and their children in Nigeria to reduce future heart health problems.

More Cardiovascular Health research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionWashington University
NIH-funded
Lab location1 site (Saint Louis, United States)
Project startSeptember 5, 2023
Project endAugust 31, 2028
Funding year2026
Award (this year)$351,882
NIH project number5R01HL168771-04
Project IDNIH-11414880 on NIH RePORTER

Who could benefit from this research

Could help

Pregnant women with obesity in Nigeria and their children, up to early childhood, who can participate with consent.

Less likely to help

Families not able to participate or who face barriers to implementing healthier lifestyles may see limited personal benefit.

What this research studies

This project will adapt a Healthy Eating Active Living program for use with pregnant women who have obesity in Nigeria and measure its impact on cardiovascular health across generations. It will combine community outreach, behavior change support, and policy-aligned strategies to promote healthier diets and physical activity during the peripartum period, infancy, and early childhood. Researchers will work with local health systems to implement the program and track outcomes in 1,000 mother-child pairs to see if healthier behaviors persist as the child grows. The study integrates national policies to support scalable interventions that could reduce future cardiovascular disease risk for families.

Why it matters

Potential benefit: If successful, families could experience healthier pregnancies and improved long-term heart health for mothers and children.

How similar studies have gone: Previous similar programs have shown promise in improving diet and activity, but this setting tests adaptation and real-world implementation.

Where this research is happening

  • Washington University
    Saint Louis, United States
    Active

Researchers

  • Principal investigator: Huffman, Mark D — Washington University
  • Study coordinator: Huffman, Mark D

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.