Enhancing CAR-T cell therapy for solid tumors
Official title: Improving CAR-T efficacy against solid tumors by expanding lymph node reservoirs of “stem-like” CAR-T cells
Funded at Fred Hutchinson Cancer Center · NIH-10912724 · Data updated 2026-11-12
This study is looking at ways to make CAR-T cell therapy work better for solid tumors like breast and lung cancer by focusing on special CAR-T cells that can survive longer, and patients may have the chance to participate in trials testing these new approaches.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $557,041 |
| NIH project number | 5R37CA276285-02 |
| Project ID | NIH-10912724 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with solid tumors such as breast cancer or lung cancer who have not responded well to existing therapies.
✕Less likely to help
Patients with hematological malignancies, such as certain types of leukemia, may not benefit from this specific research focused on solid tumors.
What this research studies
This research focuses on improving the effectiveness of CAR-T cell therapy, which has shown promise in treating blood cancers but struggles with solid tumors like breast and lung cancer. The approach involves expanding specific types of CAR-T cells that have stem-like properties, which may help them survive and function better in the challenging environment of solid tumors. By investigating the role of these cells in lymph nodes, the research aims to develop strategies that preserve their effectiveness against cancer. Patients may be involved in trials that explore these innovative therapies.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for solid tumors, potentially improving survival rates and quality of life for patients.
How similar studies have gone: While CAR-T cell therapy has been successful in treating blood cancers, this approach for solid tumors is relatively novel and has not yet been widely tested.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Srivastava, Shivani — Fred Hutchinson Cancer Center
- Study coordinator: Srivastava, Shivani
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.