Endothelial KLF4 and heart failure with preserved ejection fraction
Official title: Endothelial KLF4 regulates heart failure with preserved ejection fraction
Funded at Brown University · NIH-11429245 · Data updated 2026-11-12
A study to understand how a blood-vessel cell regulator called KLF4 might cause heart failure with normal pumping function, with hopes of guiding new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | September 3, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $525,537 |
| NIH project number | 1R01HL188492-01 |
| Project ID | NIH-11429245 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with HFpEF or individuals at risk who could be studied indirectly through related human-derived samples or future trials.
✕Less likely to help
Individuals without HFpEF or related metabolic/endothelial conditions may not directly benefit.
What this research studies
This project looks at how the endothelial protein KLF4 affects the heart under conditions that mimic HFpEF. Researchers will use animals and cellular models to turn KLF4 up or down in blood vessel lining cells and observe changes in heart function. They will also study how heart cells respond metabolically and what the single-cell RNA patterns reveal about disease processes. Advanced genomic techniques will map where KLF4 acts in the genome and how this changes during disease. The goal is to connect endothelial signals to heart failure mechanisms and identify potential therapeutic targets.
Why it matters
Potential benefit: If successful, the findings could reveal new targets to prevent or treat HFpEF by normalizing endothelial signals.
How similar studies have gone: Similar approaches have provided insight into endothelial roles in heart disease, supporting potential translational value.
Where this research is happening
-
Brown University
Providence, United States Active
Researchers
- Principal investigator: Jain, Mukesh Kumar — Brown University
- Study coordinator: Jain, Mukesh Kumar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.