Endothelial inflammation and plaque healing in atherosclerosis
Official title: Inflammation-resolution programs in endothelial cells in atherosclerosis
Funded at Albany Medical College · NIH-11376620 · Data updated 2026-11-12
This research aims to understand how the lining of blood vessels can resolve inflammation to help prevent or repair heart disease in people already taking cholesterol-lowering medicines.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | June 5, 2026 |
| Project end | February 29, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,634,428 |
| NIH project number | 1R01HL180483-01A1 |
| Project ID | NIH-11376620 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with atherosclerosis or at high risk who are receiving cholesterol-lowering treatment may be eligible to benefit from future therapies arising from this work.
✕Less likely to help
Patients without atherosclerosis or those not pursuing therapies arising from this research may not directly benefit.
What this research studies
Researchers at Albany Medical College will study how endothelial cells (the inner lining of arteries) control inflammation during atherosclerosis, especially when patients are on statins or other cholesterol treatments. They will look at signals that turn off inflammation and promote healing, including SOCS3 and molecules that resolve inflammation. The study uses laboratory experiments to map how these signals influence plaque stability and repair. The goal is to uncover new ways to boost the body’s natural ability to resolve vascular inflammation and reduce cardiovascular risk.
Why it matters
Potential benefit: If successful, the work could reveal new targets to enhance inflammation resolution and stabilize plaques, potentially lowering cardiovascular events in patients on cholesterol-lowering therapies.
How similar studies have gone: Previous studies have shown that modulating inflammatory signals can influence plaque stability, supporting potential benefits of this approach in humans.
Where this research is happening
-
Albany Medical College
Albany, United States Active
Researchers
- Principal investigator: Fredman, Gabrielle — Albany Medical College
- Study coordinator: Fredman, Gabrielle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.