Emerging nicotine analogs and device design that may affect safety
Official title: Emerging nicotine analogs and device design characteristics on toxicity assessment
Funded at University of Rochester · NIH-11446555 · Data updated 2026-11-12
This grant explores whether new nicotine-like chemicals in vaping products and how different device designs change toxin levels could affect lung health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 13, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $583,304 |
| NIH project number | 1R01CA309279-01A1 |
| Project ID | NIH-11446555 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adolescents or young adults who use or may use electronic nicotine delivery systems and could benefit from safer product guidance.
✕Less likely to help
Individuals who do not use ENDS or are not exposed to aerosolized nicotine analogs may not benefit directly.
What this research studies
Researchers at the University of Rochester will study newer nicotine analogs found in ENDS products and how different vaping device features—like wattage, coil materials, and coil resistance—alter toxic exposure. The project will use inhalation exposure models to compare these analogs with regular nicotine and assess resulting lung cell changes related to oxidative stress. Findings could inform safer product design and regulatory decisions to protect users, including teens and young adults.
Why it matters
Potential benefit: Results could lead to safer vaping products and better protections for people who use ENDS.
How similar studies have gone: Prior work shows that device design and chemical composition influence aerosol toxicity, but this project investigates emerging nicotine analogs and device variables together.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Rahman, Irfan — University of Rochester
- Study coordinator: Rahman, Irfan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.