Dynamic brain mapping in HIV and Alzheimer’s related cognitive changes
Official title: Dynamic Functional Mapping of Alzheimer's Spectrum and HIV-related Brain Dysfunction
Funded at Father Flanagan's Boys' Home · NIH-11399178 · Data updated 2026-11-12
A study to understand how brain activity differs in people living with HIV who also have memory and thinking problems, especially those related to Alzheimer’s symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Father Flanagan's Boys' Home NIH-funded |
| Lab location | 1 site (Boys Town, United States) |
| Project start | September 24, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $806,149 |
| NIH project number | 5R01NS141729-03 |
| Project ID | NIH-11399178 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with HIV who are experiencing cognitive impairment or are at risk for Alzheimer’s-related cognitive changes.
✕Less likely to help
Individuals without HIV or without cognitive impairment are less likely to benefit from this study.
What this research studies
This project aims to map how brain networks work and change over time in adults with HIV who experience cognitive impairment, including those at risk for Alzheimer’s-type symptoms. Researchers will use advanced brain imaging and neurophysiological measurements to identify distinct brain rhythms linked to thinking and memory. The goal is to pinpoint how HIV may prime the brain for cognitive decline and how that pattern compares to other aging or neurodegenerative conditions. The findings could guide better diagnosis, monitoring, and eventual targeted therapies for HIV-associated cognitive disorders.
Why it matters
Potential benefit: If successful, this work could lead to earlier detection of cognitive decline in HIV patients and inform personalized strategies to preserve memory and thinking skills.
How similar studies have gone: Previous research has linked specific brain rhythms to cognitive functions, but this study explores HIV-specific neural dynamics in depth, which is relatively novel.
Where this research is happening
-
Father Flanagan's Boys' Home
Boys Town, United States Active
Researchers
- Principal investigator: Wilson, Tony W. — Father Flanagan's Boys' Home
- Study coordinator: Wilson, Tony W.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.