Differences in tumor biology of multiple myeloma across ancestries
Official title: Differences in Tumor Biology of Multiple Myeloma
Funded at Mayo Clinic Rochester · NIH-11415779 · Data updated 2026-11-12
This NIH grant studies why multiple myeloma affects people with African ancestry differently by comparing tumor genetics and the tumor environment between patients of African and European ancestry.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $396,281 |
| NIH project number | 5R37CA272883-04 |
| Project ID | NIH-11415779 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with multiple myeloma, particularly those with African or European ancestry, or researchers with access to relevant tumor samples.
✕Less likely to help
People without multiple myeloma or those not contributing tumor samples may not benefit.
What this research studies
If you or a loved one has multiple myeloma, this project will look at how the cancer and its surrounding cells differ by ancestry using patient tumor samples from Mayo Clinic. Researchers will compare genetic changes in the tumor, the immune environment around the tumor, and how these factors relate to treatment responses and survival in AA vs EA patients. The goal is to identify ancestry-related factors that could explain differences in incidence and outcomes and point toward tailored therapies. The study uses existing patient data and tumor samples to understand biology rather than testing a new treatment in people. Results could guide more personalized approaches in the future.
Why it matters
Potential benefit: A better understanding of ancestry-related differences in multiple myeloma could lead to more personalized and effective treatment strategies.
How similar studies have gone: Prior studies suggest ancestry-related differences in cancer biology; this project aims to expand and clarify those findings in myeloma.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Baughn, Linda B — Mayo Clinic Rochester
- Study coordinator: Baughn, Linda B
Related research
Other NIH-funded projects on the same topics.
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Integrative study of multiple myeloma genetics and disease biology
A team at Dana-Farber and partners is pursuing a long-term project to understand the genetic and molecular drivers of multiple myeloma and how treatments interact with disease biology.
-
Comparative Modeling to Prevent, Detect Early, and Treat Multiple Myeloma
A research team will build and compare computer models to understand how multiple myeloma develops, can be detected earlier, and treated more effectively.
-
How LDL Affects Multiple Myeloma: New Pathways to Keep Remission
A new grant is studying how cholesterol from LDL particles fuels multiple myeloma and how this interaction influences the tumor environment and immune response, with goals to help patients stay in remission.
-
Therapy-induced senescence and immune activation in multiple myeloma
A study in people with multiple myeloma will explore how treatment-related senescence in cancer cells may stimulate the immune system and affect cancer return after standard frontline therapy.
-
BCMA CAR-T enteritis: understanding immune toxicities in multiple myeloma
A broad study to uncover why some CAR-T cell treatments targeting BCMA cause severe intestinal inflammation in people with multiple myeloma.
-
Understanding Drug-Resistant Multiple Myeloma to Stop Relapse
Researchers are studying why some myeloma cells resist treatment and how to create new therapies to prevent relapse.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.