Differences between male and female brain tumor environments affect glioblastoma growth
Project 3: Sex-specific differences in the tumor microenvironment alter glioblastoma growth
This study is looking at how brain tumors called glioblastomas behave differently in men and women, focusing on a protein that might affect tumor growth and the immune system, with the hope of finding better, more personalized treatments for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10881801 on NIH RePORTER |
What this research studies
This research investigates how the tumor microenvironment in glioblastoma, a common and aggressive brain cancer, differs between males and females. By studying genetically modified mice, researchers are examining the role of a specific protein, JAM-A, which appears to influence tumor growth and immune response differently based on sex. The goal is to understand these differences better to improve treatment strategies for glioblastoma patients. This work could lead to more personalized therapies that consider sex-specific factors in cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with glioblastoma, particularly those who are male or female and may benefit from sex-specific treatment approaches.
Not a fit: Patients with glioblastoma who do not identify as male or female, or those with other types of brain tumors, may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and tailored treatments for glioblastoma patients based on their sex.
How similar studies have performed: Other research has shown promising results in understanding sex differences in cancer biology, suggesting that this approach could yield valuable insights.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Lathia, Justin D. — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Lathia, Justin D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.