Developing tools to evaluate drugs that improve tissue barrier function in diseases
Official title: MPS Qualifications
Funded at University of Rochester · NIH-11005758 · Data updated 2026-11-12
This study is working on new tools to help test how well medications can move cells and molecules through body tissues, which is important for treating infections and inflammation, using a special system that simulates human tissue.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | January 15, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $498,357 |
| NIH project number | 5U2CAG088071-02 |
| Project ID | NIH-11005758 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from autoimmune diseases or conditions that affect tissue barrier function.
✕Less likely to help
Patients with conditions unrelated to tissue barrier dysfunction may not benefit from this research.
What this research studies
This research focuses on creating five FDA-qualified drug development tools that assess how well drugs can improve the transport of cells and molecules across tissue barriers, which is crucial in treating infections and inflammation. The approach involves using a specialized microphysiological system that mimics human tissue environments, allowing for the study of multiple cell types and their interactions over time. By addressing the limitations of existing systems, this research aims to provide a more effective platform for drug discovery and efficacy testing.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for diseases that involve tissue barrier dysfunction, improving patient outcomes.
How similar studies have gone: While the approach is innovative, similar research has shown promise in developing drug evaluation tools, indicating potential for success.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Mcgrath, James L — University of Rochester
- Study coordinator: Mcgrath, James L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.