Developing tools to access all brain cell types for better understanding and treatment of neurological disorders
A germline- and promoter-independent strategy to gain access to all cell types in the brain
This study is working on new tools to help scientists better understand different types of brain cells, which could lead to improved treatments for brain-related conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10651435 on NIH RePORTER |
What this research studies
This research aims to create innovative tools that allow scientists to study various cell types in the brain more effectively. By utilizing advanced technologies like high-throughput sequencing and a novel AAV-based targeting system, the project seeks to bypass traditional methods that are often labor-intensive and limited. The goal is to generate a library of tools that can target 50 different brain cell types in both mice and marmosets, facilitating a deeper understanding of brain function and the development of treatments for neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological disorders or conditions that affect brain function.
Not a fit: Patients with conditions unrelated to neurological disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in the treatment of neurological disorders by providing better tools for understanding brain cell functions.
How similar studies have performed: Other research has shown success with similar CRISPR-based approaches, indicating potential for this novel methodology.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Lu, Baisong — Wake Forest University Health Sciences
- Study coordinator: Lu, Baisong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.