Developing new tools to measure electrical signals in brain cells using advanced imaging techniques
Red-shifted voltage indicators for two-photon all-optical physiology and multi-spectral imaging
This study is working on new tools to help scientists see how brain cells talk to each other in real-time, especially in awake animals, which could lead to better understanding of brain function and help with brain-related conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11075901 on NIH RePORTER |
What this research studies
This research focuses on creating innovative genetically encoded voltage indicators (GEVIs) that can effectively measure electrical signals in neurons during two-photon microscopy. By enhancing the ability to visualize these signals in real-time, the study aims to improve our understanding of how brain cells communicate and process information, particularly in awake and behaving animals. The approach involves developing red-shifted GEVIs that can work alongside existing imaging tools, allowing for deeper insights into neuronal activity and its implications for neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological disorders or conditions that affect brain function, as well as healthy volunteers for comparative studies.
Not a fit: Patients with conditions unrelated to neuronal activity or those who are not suitable for imaging studies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic and therapeutic strategies for neurological disorders by providing clearer insights into brain function.
How similar studies have performed: Previous research has shown promise in using genetically encoded indicators for monitoring neuronal activity, suggesting that this approach could yield significant advancements in neuroscience.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: St-Pierre, Francois — Baylor College of Medicine
- Study coordinator: St-Pierre, Francois
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.