Developing new methods to measure and potentially slow down aging
Official title: Using causal aging biomarkers and protein design to develop novel anti-aging interventions
Funded at Brigham and Women's Hospital · NIH-10973155 · Data updated 2026-11-12
This study is looking at how changes in our DNA can help predict how old our bodies really are, with the hope of finding new ways to slow down aging and improve health for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 3, 2024 |
| Project end | September 2, 2025 |
| Funding year | 2024 |
| Award (this year) | $37,463 |
| NIH project number | 1F99AG088431-01 |
| Project ID | NIH-10973155 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults who are interested in understanding their biological age and potential interventions to improve their health.
✕Less likely to help
Patients who are not elderly or do not have age-related health concerns may not receive direct benefits from this research.
What this research studies
This research investigates how specific changes in DNA methylation can be used to create accurate models for predicting biological age. By understanding the causal relationships between these changes and aging, the researchers aim to develop new interventions that could slow down the aging process. The project utilizes advanced machine learning techniques and a large database of biological samples to enhance the reliability of aging predictions. Patients may benefit from insights into how aging affects their health and potential new therapies that could arise from this work.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that slow down the aging process and improve health outcomes for older adults.
How similar studies have gone: Previous research has shown promise in using epigenetic clocks to understand aging, but this approach aims to enhance reliability and causal understanding, making it a novel endeavor.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Ying, Kejun — Brigham and Women's Hospital
- Study coordinator: Ying, Kejun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.