Developing new methods to engineer and study viruses in the lab
Virus, Vector and Cell Culture Core
This study is exploring how certain viruses, like Epstein-Barr and Kaposi Sarcoma-associated Herpesvirus, work and how we might use that knowledge to develop better treatments for patients, especially through new gene therapies.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10914927 on NIH RePORTER |
What this research studies
This research focuses on creating and manipulating viruses, specifically the Epstein-Barr Virus (EBV) and Kaposi Sarcoma-associated Herpesvirus (KSHV), to better understand their biology and potential treatments. The project involves designing recombinant viruses, producing viral vectors, and establishing 3D organoid cultures to study infections in a controlled environment. Patients may benefit from advancements in gene therapy and targeted treatments that arise from this innovative approach to viral research.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals affected by diseases related to EBV or KSHV, such as certain lymphomas or other herpesvirus-related conditions.
Not a fit: Patients with conditions unrelated to EBV or KSHV may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for diseases caused by EBV and KSHV, improving patient outcomes.
How similar studies have performed: Previous research has shown success in using similar viral engineering techniques to develop targeted therapies, indicating a promising avenue for further exploration.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Robertson, Erle S. — University of Pennsylvania
- Study coordinator: Robertson, Erle S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.