Developing new methods to analyze proteins and nucleic acids using advanced mass spectrometry techniques.
Official title: Novel Ion Chemistry and Instrument Development for the Characterization of Proteins, Nucleic Acids, and Heterogeneous Bio-complexes via Tandem Mass Spectrometry
Funded at Purdue University · NIH-11077303 · Data updated 2026-11-12
This study is working on better ways to analyze big biological molecules like proteins and DNA without breaking them apart, which could help us learn more about how they work and their role in diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $365,948 |
| NIH project number | 5R35GM153191-02 |
| Project ID | NIH-11077303 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve complex biological molecules, such as certain cancers or genetic disorders.
✕Less likely to help
Patients with conditions unrelated to protein or nucleic acid abnormalities may not benefit from this research.
What this research studies
This research focuses on improving mass spectrometry techniques to analyze large biological molecules like proteins and nucleic acids without breaking them down into smaller pieces. By using innovative ion chemistries and new instruments, the project aims to enhance the ability to measure and characterize complex mixtures of these macromolecules. This approach could provide more detailed information about the structure and function of these biological components, which is crucial for understanding various diseases and biological processes.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnostic tools and treatments for diseases by providing deeper insights into the molecular makeup of proteins and nucleic acids.
How similar studies have gone: Previous research in mass spectrometry has shown significant advancements in protein analysis, indicating that this novel approach could build on established successes.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Mcluckey, Scott a — Purdue University
- Study coordinator: Mcluckey, Scott a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.