Developing new methods for incorporating fluorine-18 into complex molecules for imaging
Metal Fluorination For biomolecules: Expanding The Radiofluorination Toolbox
This study is working on new ways to make better imaging tools for diagnosing cancer, especially by improving how we use a special chemical called fluorine-18 in complex molecules, which could help doctors see and treat conditions like prostate cancer more effectively.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11057029 on NIH RePORTER |
What this research studies
This research focuses on improving molecular imaging techniques by developing innovative methods for incorporating fluorine-18 into complex biomolecules. The approach involves creating irreversible metal-fluorine bonds, which could enhance the effectiveness of existing fluorination methods. By evaluating different metal centers for their pharmacological properties, the research aims to create more efficient imaging agents that can also be paired with therapeutic isotopes. This could lead to better diagnostic tools for conditions like cancer, particularly targeting prostate-specific membrane antigen (PSMA) and carbonic anhydrase IX (CAIX).
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing evaluation for prostate cancer or other conditions where advanced imaging techniques are beneficial.
Not a fit: Patients who do not have conditions requiring advanced molecular imaging or those who are not candidates for imaging studies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective imaging techniques that improve the diagnosis and treatment of various cancers.
How similar studies have performed: Previous research has shown promise in enhancing imaging techniques through novel radiochemistry approaches, indicating potential for success in this area.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Carroll, Laurence — Johns Hopkins University
- Study coordinator: Carroll, Laurence
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.